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Pubmed for Handhelds

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  • Title: Hedgehog Pathway Inhibition.
    Author: Sekulic A, Von Hoff D.
    Journal: Cell; 2016 Feb 25; 164(5):831. PubMed ID: 26919418.
    Abstract:
    The hedgehog (Hh) signaling pathway is aberrantly activated in a majority of basal cell carcinomas (BCC). Vismodegib and sonidegib are targeted inhibitors of Smoothened (SMO). Both drugs are approved for use in locally advanced BCC (laBCC), with vismodegib also approved for metastatic BCC (mBCC).
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