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  • Title: A case of aminoglycosides induced retinal toxicity treated with megadoses of steroids and an intravitreal dexamethasone implant (Ozurdex(®)).
    Author: Hernández Pardines F, Tapia-Quijada H, Hueso-Abancens JR.
    Journal: Arch Soc Esp Oftalmol; 2016 Jun; 91(6):288-91. PubMed ID: 26922137.
    Abstract:
    CASE REPORT: The case is described of a patient who had a sudden loss of vision in her right eye after glaucoma surgery. A diagnosis of retinal toxicity due to tobramycin (an aminoglycoside) was reached, which was characterised by retinal whitening with a red cherry stain, macular oedema, and vasculitis that progressed to papillary and macular atrophy with arteriolar sclerosis. Given the severity of symptoms an early attempt was made with megadoses of steroids and an intravitreal dexamethasone implant (Ozurdex®, Allergan S.A.), without response. DISCUSSION: Aminoglycoside toxicity is a rare, idiosyncratic, very serious complication for which there is no effective treatment.
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