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  • Title: Fabrication of biodegradable PEG-PLA nanospheres for solubility, stabilization, and delivery of curcumin.
    Author: Liang H, Friedman JM, Nacharaju P.
    Journal: Artif Cells Nanomed Biotechnol; 2017 Mar; 45(2):297-304. PubMed ID: 26924283.
    Abstract:
    Curcumin is an effective and safe anticancer agent, and also known to induce vasodilation, but its hydrophobicity limits its clinical application. In this study, a simple emulsion method was developed to prepare biodegradable poly (ethylene glycol)-poly (lactic acid) (PEG-PLA) nanospheres to encapsulate curcumin to improve its solubility and stability. The nanoparticle size was around 150 nm with a narrow size distribution. Fluorescence microscopy showed that curcumin encapsulated PEG-PLA nanospheres were taken up rapidly by Hela and MDA-MB-231 cancer cells. This novel nanoparticulate carrier may improve the bioavailability of curcumin without affecting its anticancer properties.
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