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  • Title: Urinary protein excretion following intravenously administered ionic and non-ionic contrast media in man.
    Author: Skovgaard N, Holm J, Hemmingsen L, Skaarup P.
    Journal: Acta Radiol; 1989; 30(5):517-9. PubMed ID: 2692667.
    Abstract:
    Urinary protein excretion following intravenous administration of the radiographic contrast media (CM) diatrizoate (ionic) and iopromide (non-ionic) was examined in 20 patients with normal renal function. Neither of the two CM had any effect on the 24-h urinary excretion of albumin (a marker of glomerular proteinuria). The 24-h urinary excretion of the retinol-binding protein (a marker of low molecular weight or tubular proteinuria) and the folate binding protein, a protein localized in the brush-border membranes of the proximal tubular cells, showed a statistically significant transient increase the day after diatrizoate injection, whereas no increase was observed after iopromide. Thus, only a minimal and temporary disturbance of the renal proximal tubular function was observed after diatrizoate injection in patients with normal renal function.
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