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  • Title: Mutations in ADE3 reduce the efficiency of the omnipotent suppressor sup45-2.
    Author: Song JM, Liebman SW.
    Journal: Curr Genet; 1989 Dec; 16(5-6):315-21. PubMed ID: 2692849.
    Abstract:
    Mutations in a known yeast gene, ADE3, were shown to act as an antisuppressor, reducing the efficiency of the omnipotent suppressor, sup45-2. The ADE3 locus encodes the trifunctional enzyme C1-tetrahydrofolate synthase, which is required for the biosynthesis of purines, thymidylate, methionine, histidine, pantothenic acid and formylmethionyl-tRNA(fMet. The role of this enzyme in translational fidelity had not previously been suspected.
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