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  • Title: Hemorheological effects of oral contraceptives.
    Author: Ernst E, Schmölzl C, Matrai A, Schramm W.
    Journal: Contraception; 1989 Nov; 40(5):571-80. PubMed ID: 2692965.
    Abstract:
    To determine the hemorheological effects of oral contraceptives, 50 healthy young women took no medication for 3 cycles. Subsequently they were randomized into group A and B. Group A took Diane-35, B took Microgynon each for 6 cycles. Finally 3 cycles without medication followed. Blood viscosity was quantified by ex vivo measurements of hematocrit, blood and plasma viscosity, red cell filterability, fibrinogen and colloid oncotic pressure. In group A fibrinogen rose at the end of the medication phase. In group B fibrinogen, blood and plasma viscosity increased on medication. The former 2 variables remained elevated even after discontinuation of the oral contraceptive. The data combined with those from the literature suggest that low-dose oral contraceptives lead to no biologically meaningful changes in blood rheology while higher doses induce limitations of blood fluidity which could be involved in the increment of cardiovascular risk by these medications. To determine the hemorheological effects of oral contraceptives (OCs), 50 health young women took no medication for 3 cycles. Subsequently, they were randomized into 2 groups: groups A took Diane-35 and group B took Microgynon each for 6 cycles. Following that course, 3 cycles without medication were evaluated. Blood viscosity was quantified by ex vivo measurements of hematocrit, blood and plasma viscosity, red cell filterability, fibrinogen, and colloid oncotic pressure. In group A, fibrinogen rose at the end of the medication phase; in group B, fibrinogen, blood, and plasma viscosity increased during medication. The former 2 variables remained elevated even after discontinuation of the OC. The data combined with those from the literature suggest that low-dose OCs lead to no biologically meaningful changes in blood rheology while higher doses induce limitations of blood fluidity which could increases cardiovascular risk in patients.
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