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  • Title: A 12-lead ECG-method for quantifying ischemia-induced QRS prolongation to estimate the severity of the acute myocardial event.
    Author: Elmberg V, Almer J, Pahlm O, Wagner GS, Engblom H, Ringborn M.
    Journal: J Electrocardiol; 2016; 49(3):272-7. PubMed ID: 26931515.
    Abstract:
    INTRODUCTION: Studies have shown terminal QRS distortion and resultant QRS prolongation during ischemia to be a sign of low cardiac protection and thus a faster rate of myocardial cell death. A recent study introduced a single lead method to quantify the severity of ischemia by estimating QRS prolongation. This paper introduces a 12-lead method that, in contrast to the previous method, does not require access to a prior ECG. METHODS: QRS duration was estimated in the lead that showed the maximal ST deviation according to a novel method. The degree of prolongation was determined by subtracting the measured QRS duration in the lead that showed the least ST deviation. RESULTS: The method is demonstrated in examples of acute occlusion in two of the major coronary arteries. CONCLUSION: This paper presents a 12-lead method to quantify the severity of ischemia, by measuring QRS prolongation, without requiring comparison with a previous ECG.
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