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  • Title: Uracil Nucleosides with Reactive Group at C5 Position: 5-(1-Halo-2-sulfonylvinyl)uridine Analogues.
    Author: Liang Y, Suzol SH, Wen Z, Artiles AG, Mathivathanan L, Raptis RG, Wnuk SF.
    Journal: Org Lett; 2016 Mar 18; 18(6):1418-21. PubMed ID: 26933954.
    Abstract:
    The transition-metal-catalyzed or radical-mediated halosulfonylation of 5-ethynyluridine provided (E)-(1-halo-2-tosylvinyl)uridines. These (β-halo)vinyl sulfones undergo efficient stereoselective addition-elimination with amines or thiols to provide Z-β-aminovinyl or E-β-thiovinyl sulfones tethered to the C5 position of the uracil ring.
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