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  • Title: Executive function relates to surface area of frontal and temporal cortex in very-low-birth-weight late teenagers.
    Author: Østgård HF, Sølsnes AE, Bjuland KJ, Rimol LM, Martinussen M, Brubakk AM, Håberg AK, Skranes J, Løhaugen GC.
    Journal: Early Hum Dev; 2016 Apr; 95():47-53. PubMed ID: 26939083.
    Abstract:
    BACKGROUND: Being born with very low birth weight (VLBW; birth weight (BW) ≤1500 g) is associated with increased risk of maldevelopment of the immature brain which may affect neurological functioning. Deficits in attention and executive function problems have been reported in VLBW survivors compared with healthy subjects. AIMS: The aim of this study was to evaluate attention and executive functions and to relate the clinical test results to cortical morphometry findings in VLBW young adults compared with term-born controls. STUDY DESIGN: Prospective follow-up study of three year cohorts of VLBW and control children from birth to adulthood. OUTCOME MEASURES: A comprehensive neuropsychological test battery was administered to 55 VLBW subjects born preterm (mean BW: 1217 g) and 81 term-born controls (mean BW: 3707 g) at age 19-20. Cerebral MRI was successfully obtained in 46 VLBW subjects and 61 controls. The FreeSurfer software package was applied for the cortical analyses based on T1-weighted MRI images. RESULTS: The VLBW group obtained inferior scores on 15 of the 29 neuropsychological measures assessing attention and executive function and on both the attention and executive function domain scores. We found positive correlations between the executive function domain score and cortical surface area, especially in the antero-medial frontal and the temporal lobes of the brain in the VLBW group. CONCLUSION: Young adults born with VLBW show deficits in attention and executive function compared with controls. The executive problems were related to smaller cortical surface area in brain regions known to be involved in higher order cognitive functioning.
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