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  • Title: HPA axis disturbance in obsessive-compulsive disorder.
    Author: Coryell WH, Black DW, Kelly MW, Noyes R.
    Journal: Psychiatry Res; 1989 Dec; 30(3):243-51. PubMed ID: 2694203.
    Abstract:
    Twenty nondepressed outpatients with DSM-III obsessive-compulsive disorder entered a 10-week placebo-controlled study of clomipramine and underwent a 1-mg dexamethasone suppression test (DST) at baseline; 11 had a repeat DST at the end of treatment: Nonsuppression was rare. When compared to 82 previously described outpatients with panic disorder studied in a similar fashion, OCD patients had postdexamethasone cortisol values that were substantially lower and more stable over time. Results within the OCD group closely resembled those from a group of never-ill controls.
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