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  • Title: Cytokeratin 7-negative mammary Paget's disease: A diagnostic pitfall.
    Author: Ozerdem U, McNiff JM, Tavassoli FA.
    Journal: Pathol Res Pract; 2016 Apr; 212(4):279-81. PubMed ID: 26944832.
    Abstract:
    Pathologists should be aware of the existence of a rare CK7-negative variant of breast carcinoma in general, and of Paget's disease in particular. Cytokeratin 7-negative Paget's disease and CK7-negative ductal intraepithelial neoplasia (ductal carcinoma in situ) present a major diagnostic challenge for pathologists since there is limited awareness of their existence. When there is classic Paget's morphology on H&E sections, GATA3 positivity should resolve any doubts about the diagnosis in the setting of a CK7-negative neoplastic cell population.
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