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Pubmed for Handhelds

PUBMED FOR HANDHELDS

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  • Title: A double-blind, cross-over trial with madopar HBS in patients with Parkinson's disease.
    Author: De Michele G, Mengano A, Filla A, Trombetta L, Campanella G.
    Journal: Acta Neurol (Napoli); 1989 Dec; 11(6):408-14. PubMed ID: 2694799.
    Abstract:
    Fourteen patients with Parkinson's disease and motor fluctuations were given 125 mg of Madopar HBS or placebo twice a day in addition to their optimal standard Madopar treatment in a double-blind, cross-over study. Clinical response was evaluated by the King's College Hospital Parkinson's Disease Rating Scale, the Mobility in Bed Scale and self-scoring diaries. A significant improvement with the drug was found according to the rating scales, whereas evaluation by self-scoring diaries showed no significant changes. In three patients we observed worsening of abnormal involuntary movements. The present trial suggests that a low dose of Madopar HBS can be useful in addition to levodopa therapy in some patients on long-term treatment.
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