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  • Title: Direct Catalytic Asymmetric Mannich Reactions for the Construction of Quaternary Carbon Stereocenters.
    Author: Trost BM, Saget T, Hung CI.
    Journal: J Am Chem Soc; 2016 Mar 23; 138(11):3659-62. PubMed ID: 26952276.
    Abstract:
    Herein, we report a Zn-ProPhenol catalyzed Mannich reaction using α-branched ketones as nucleophilic partners for the direct enantio- and diastereoselective construction of quaternary carbon stereocenters. The reaction can be run on a gram-scale with a low catalyst loading without impacting its efficiency. Moreover, the Mannich adducts can be further elaborated with complete diastereocontrol to access molecules possessing complex stereotriads.
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