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  • Title: Guinea-pig tracheal epithelium and endothelin.
    Author: Hay DW.
    Journal: Eur J Pharmacol; 1989 Nov 21; 171(2-3):241-5. PubMed ID: 2695340.
    Abstract:
    Removal of the epithelium increased the responsiveness of isolated guinea-pig trachea to the contractile effects of endothelin. This phenomenon was observed in the presence of indomethacin (5 microM), captopril (10 microM), bacitracin (20 micrograms/ml) or leupeptin (50 microM), but was inhibited by phosphoramidon (10 microM). Bacitrain enhanced contraction produced by endothelin. The increased responsiveness of denuded guinea-pig trachea to endothelin may be due to removal of an epithelium-derived phosphoramidon-sensitive peptidase.
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