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  • Title: Immunological evaluation of the entirely carbohydrate-based Thomsen-Friedenreich - PS B conjugate.
    Author: Trabbic KR, Bourgault JP, Shi M, Clark M, Andreana PR.
    Journal: Org Biomol Chem; 2016 Apr 07; 14(13):3350-5. PubMed ID: 26958987.
    Abstract:
    PS B, a naturally occurring CD4(+) T-cell simulating zwitterionic polysaccharide from Bacteroides fragilis ATCC 25285/NCTC 9343, was conjugated with aminooxy Thomsen Friedenreich (TF or T) [α-d-Gal-(1,3)-β-d-GalNAc-ONH2] tumor antigen. Immunization in Jax C57BL/6, followed by ELISA revealed IgM and IgG antibody TF specificity. FACS data noted preferential binding to TF-laced MCF-7 cells but not to HCT-116 cells.
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