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  • Title: [Laboratory and oligobiopsy studies of the liver in patients with psoriasis treated by the combination of Tigason-PUVA-cignoline (RePUVA+C)].
    Author: Ruszczak Z, Biernat S, Prószyńska-Kuczyńska W, Drobnik G, Drobnik S.
    Journal: Przegl Dermatol; 1989; 76(2):104-9. PubMed ID: 2695977.
    Abstract:
    In 10 patients with generalized psoriasis treated by this method biochemical and histological examinations of liver biopsy specimens were done before and after 60 days of the treatment. In some cases a transient rise of A1AT activity, raised activity of alkaline phosphatase and gamma-glutamyltranspeptidase were noted. Histological examinations demonstrated slight hepatocellular damage with microfocal necrosis, fatty infiltration of some cells and increase in the structural elements of cytoplasm.
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