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  • Title: [Allopurinol hypersensitivity syndrome. A report of two cases].
    Author: Rodríguez-Arámbula A, Arenas-Velázquez E, Castanedo-Cázares JP, Hernández-Blanco D, Oros-Ovalle C, Torres-Álvarez B.
    Journal: Rev Med Inst Mex Seguro Soc; 2016; 54(2):261-4. PubMed ID: 26960055.
    Abstract:
    Patients in treatment with allopurinol are in risk of having life threatening adverse reactions particularly at the beginning of the treatment. Two percent of the patients prescribed with this drug have associated severe cutaneous adverse reactions. We present two cases of allopurinol hypersensitivity syndrome in mexican patients in which asymptomatic hyperuricemia was the indication to its use. The general physician and the specialist must be alert of this syndrome that causes elevate morbidity and mortality. Los pacientes bajo tratamiento con alopurinol pueden presentar reacciones adversas potencialmente mortales, particularmente al inicio del tratamiento. Las reacciones cutáneas adversas por alopurinol tienen una prevalencia aproximada del 2 %. Presentamos dos casos de síndrome de hipersensibilidad por alopurinol en pacientes mexicanos en quienes la hiperuricemia asintomática fue la indicación para su uso. El médico general y el especialista deben estar alerta ante este síndrome que ocasiona alta morbilidad y mortalidad.
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