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Title: Platelet VIII pack evades immune detection. Author: Ragni MV. Journal: Blood; 2016 Mar 10; 127(10):1222-4. PubMed ID: 26965921. Abstract: In this issue of Blood, Chen et al demonstrate that platelets expressing factor VIII (FVIII) shield FVIII from immune detection. In the naive FVIII null hemophilia A (HA) mouse, platelet-derived VIII prevents both a primary and memory anti-FVIII immune response, and together with total body irradiation, suppresses anti-FVIII immune response.[Abstract] [Full Text] [Related] [New Search]