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  • Title: An Intestinal Inflammasome - The ILC3-Cytokine Tango.
    Author: Gonçalves P, Di Santo JP.
    Journal: Trends Mol Med; 2016 Apr; 22(4):269-271. PubMed ID: 26965960.
    Abstract:
    The inflammasome is a key regulator of immune responses in the gut. Two recent studies in the journal Cell demonstrate that epithelial inflammasome activation and IL-18 secretion can control intestinal homeostasis or induce autoinflammation. ILC3 cells are triggered to secrete IL-22, regulating IL-18 expression in epithelial cells, in turn modulating homeostasis and inflammation.
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