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  • Title: PI3K/Akt/mTOR signaling pathway and targeted therapy for glioblastoma.
    Author: Li X, Wu C, Chen N, Gu H, Yen A, Cao L, Wang E, Wang L.
    Journal: Oncotarget; 2016 May 31; 7(22):33440-50. PubMed ID: 26967052.
    Abstract:
    Glioblastoma multiform (GBM) is the most common malignant glioma of all the brain tumors and currently effective treatment options are still lacking. GBM is frequently accompanied with overexpression and/or mutation of epidermal growth factor receptor (EGFR), which subsequently leads to activation of many downstream signal pathways such as phosphatidylinositol 3-kinase (PI3K)/Akt/rapamycin-sensitive mTOR-complex (mTOR) pathway. Here we explored the reason why inhibition of the pathway may serve as a compelling therapeutic target for the disease, and provided an update data of EFGR and PI3K/Akt/mTOR inhibitors in clinical trials.
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