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  • Title: High-resolution intracranial vessel wall imaging using 3D CUBE T1 weighted sequence.
    Author: Li ML, Xu YY, Hou B, Sun ZY, Zhou HL, Jin ZY, Feng F, Xu WH.
    Journal: Eur J Radiol; 2016 Apr; 85(4):803-7. PubMed ID: 26971427.
    Abstract:
    PURPOSE: To evaluate the feasibility of high-resolution 3D CUBE T1WI for intracranial vessel wall imaging. METHODS: High-resolution 3D CUBE T1 weighted intracranial vessel wall images (0.4 mm × 0.4 mm × 0.4 mm) of 50 patients were retrospectively evaluated. A 5-point scale (1 poor, 5 excellent) was used to score the imaging quality for displaying the vessel wall of every intracranial artery segments. The inter-observer and intra-observer reproducibility of identifying plaques, intraplaque hemorrhage/luminal thrombosis, and wall enhancement were calculated. RESULTS: Totally 893 artery segments were evaluated. 3D CUBE T1WI displayed the arteries wall and lumen clearly, with the highest score (4.920 ± 0.837) for the C6-7 segments and the lowest (3.370 ± 1.107) for the C3 segments of the internal carotid artery (ICA). Both intra-observer and inter-observer reproducibility were high for identification of normal walls (κ=0.928, 95% confidence interval [CI] 0.891-0.954; κ=0.911, CI 0.868-0.940), plaque (κ=0.924, CI 0.884-0.954; κ=0.907, CI 0.866-0.943), luminal thrombosis (κ=1.000, CI 1.000-1.000; κ=1.000, CI 1.000-1.000), and wall enhancement (κ=1.000, CI 1.000-1.000; κ=0.914, CI 0.863-0.961). CONCLUSIONS: High-resolution 3D CUBE T1WI displayed intracranial wall and lumen clearly, and detected intracranial artery abnormalities with high reproducibility.
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