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Pubmed for Handhelds

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  • Title: A Mixed-Signal VLSI System for Producing Temporally Adapting Intraspinal Microstimulation Patterns for Locomotion.
    Author: Mazurek KA, Holinski BJ, Everaert DG, Mushahwar VK, Etienne-Cummings R.
    Journal: IEEE Trans Biomed Circuits Syst; 2016 Aug; 10(4):902-11. PubMed ID: 26978832.
    Abstract:
    Neural pathways can be artificially activated through the use of electrical stimulation. For individuals with a spinal cord injury, intraspinal microstimulation, using electrical currents on the order of 125 μ A, can produce muscle contractions and joint torques in the lower extremities suitable for restoring walking. The work presented here demonstrates an integrated circuit implementing a state-based control strategy where sensory feedback and intrinsic feed forward control shape the stimulation waveforms produced on-chip. Fabricated in a 0.5 μ m process, the device was successfully used in vivo to produce walking movements in a model of spinal cord injury. This work represents progress towards an implantable solution to be used for restoring walking in individuals with spinal cord injuries.
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