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  • Title: Short-term effect of captopril and nifedipine on micro-albuminuria induced by exercise in hypertensive diabetic patients.
    Author: Romanelli G, Giustina A, Agabiti-Rosei E, Bossoni S, Girelli A, Muiesan ML, Muiesan G, Giustina G.
    Journal: J Hypertens Suppl; 1989 Dec; 7(6):S312-3. PubMed ID: 2698946.
    Abstract:
    Physical exercise can induce micro-albuminuria, a urinary albumin excretion rate of 20-200 micrograms/min, in diabetics without micro-albuminuria at rest (stage II of diabetic nephropathy). The aim of the present study was to evaluate the acute effects of captopril, an angiotensin converting enzyme (ACE) inhibitor, and nifedipine, a calcium channel blocker, on exercise-induced micro-albuminuria in hypertensive diabetics with stage II nephropathy. Eleven hypertensive World Health Organisation (WHO) stages I-II non-obese diabetics (five insulin-dependent diabetics, six non-insulin dependent diabetics) underwent five submaximal cycloergometric tests, the first two in basal conditions, the other three after 24-h administration of captopril (25 mg twice a day), placebo (1 tablet twice a day) or nifedipine AR (20 mg twice a day) according to a randomized double-blind design. Our results demonstrate that despite a lower reduction in exercise blood pressure, captopril is more effective than nifedipine in blunting diabetic exercise-induced micro-albuminuria.
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