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  • Title: Asymmetric Total Synthesis of Propindilactone G, Part 1: Initial Attempts towards the Synthesis of Schiartanes.
    Author: Xu LM, You L, Shan ZH, Yu RC, Zhang B, Li YH, Shi Y, Chen JH, Yang Z.
    Journal: Chem Asian J; 2016 May 06; 11(9):1406-13. PubMed ID: 26991268.
    Abstract:
    Our first-generation synthetic study towards the total synthesis of propindilactone G (1) and its analogues is reported. The key synthetic steps were an intramolecular Pauson-Khand reaction (PKR) and a vinylogous Mukaiyama reaction (VMAR). The stereoselective synthesis of the CDE ring moiety with an all-carbon quaternary center through a PKR was difficult, whilst a VMAR afforded a product with the opposite stereochemistry at the C20 position on the side chain. These results led us to redesign our synthetic strategy for the total synthesis of compound 1.
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