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  • Title: A suppressive mechanism counteracts the production of anti-idiotype antibody.
    Author: Korec E, Korcová J, Hlozánek I.
    Journal: Folia Biol (Praha); 1989; 35(5):347-50. PubMed ID: 2699293.
    Abstract:
    BALB/c mice were repeatedly, at two-week intervals, immunized with monoclonal antibody against hepatitis B surface antigen and their sera were titrated for anti-idiotype antibody. The highest titres appeared after 1-4 immunizations. Further immunizations led to fast disappearance of the anti-idiotype antibody. These data suggest that anti-idiotype antibody production is a rather complicated process in which some suppressive mechanism is involved.
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