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  • Title: Fluoxetine compared with amitriptyline in elderly depression: a controlled clinical trial.
    Author: Altamura AC, De Novellis F, Guercetti G, Invernizzi G, Percudani M, Montgomery SA.
    Journal: Int J Clin Pharmacol Res; 1989; 9(6):391-6. PubMed ID: 2699465.
    Abstract:
    Twenty-eight elderly inpatients suffering from major depressive episodes (diagnosed according to DSM III) received randomly, on a double-blind basis, amitriptyline (75 mg/die) or fluoxetine (20 mg/die) for five weeks. There were four drop-outs in the amitriptyline group and two drop-outs in the fluoxetine group. Both groups showed a significant amelioration at the end point for Hamilton Rating Scale of Depression scores compared to the baseline value. Anticholinergic side-effects were significantly more severe in the amitriptyline group. Weight gain was detected only in patients receiving amitriptyline.
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