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  • Title: Self-assembly of a 5-fluorouracil-dipeptide hydrogel.
    Author: Sun Y, Kaplan JA, Shieh A, Sun HL, Croce CM, Grinstaff MW, Parquette JR.
    Journal: Chem Commun (Camb); 2016 Apr 18; 52(30):5254-7. PubMed ID: 26996124.
    Abstract:
    The self-assembly of 5-fluorouracil dilysine conjugates into self-supporting hydrogels, comprised of entangled nanofibers or rigid nanotubes with diameters of 10 and 16 nm, respectively, is reported. The rate of release of 5-Fu from the conjugates was highly dependent on concentration in solution, whereas, release from the fully formed hydrogels was significantly slower. The 5-Fu conjugate also exhibited promising in vitro cytotoxicity against human tumor cell lines A549, H460 and H23.
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