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  • Title: Early recurrence of proliferative glomerulonephritis with monoclonal immunoglobulin deposits in a renal allograft.
    Author: Tewari R, Joshi K, Kumar A, Rayat CS, Iyer R, Sakhuja V, Minz M.
    Journal: Saudi J Kidney Dis Transpl; 2016 Mar; 27(2):381-5. PubMed ID: 26997395.
    Abstract:
    Proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMIDs) is a clinico-pathologic entity, the recurrence of which in the renal allograft has only recently been described. A 55-year-old male presented with rapid deterioration of renal function. Light microscopy showed membranoproliferative glomerulonephritis with kappa light chain restriction and only one sub-class of IgG. He subsequently underwent renal transplant. Two months later, he developed acute graft dysfunction. Renal biopsy showed a recurrence of the disease. Work up for multiple myeloma was positive. Membranoproliferative pattern of injury in the posttransplant setting has a wide range of differential diagnosis, PGNMID being one of them.
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