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  • Title: Toward DNA electrochemical sensing by free-standing ZnO nanosheets grown on 2D thin-layered MoS2.
    Author: Yang T, Chen M, Kong Q, Luo X, Jiao K.
    Journal: Biosens Bioelectron; 2017 Mar 15; 89(Pt 1):538-544. PubMed ID: 27005453.
    Abstract:
    Very recently, the 2-dimensional MoS2 layer as base substrate integrated with other materials has caused people's emerging attention. In this paper, a thin-layered MoS2 was prepared through an ultrasonic exfoliation method from bulk MoS2 and then the free-standing ZnO nanosheet was electrodeposited on the MoS2 scaffold for DNA sensing. The ZnO/MoS2 nanocomposite revealed smooth and vertical nanosheets morphology by scanning electron microscopy, compared with the sole MoS2 and sole ZnO. Importantly, the partially negative charged MoS2 layer is beneficial to the nucleation and growth of ZnO nanosheets under the effect of electrostatic interactions. Classic methylene blue, which possesses different affinities to dsDNA and ssDNA, was adopted as the measure signal to confirm the immobilization and hybridization of DNA on ZnO nanosheets and pursue the optimal synthetic conditions. And the results demonstrated that the free-standing ZnO/MoS2 nanosheets had low detection limit (6.6×10-16M) and has a positive influence on DNA immobilization and hybridization.
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