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  • Title: Synthesis and antiinflammatory/analgesic activities of N-heterocyclic carboxamides of thiopyrano-1,2-benzothiazine.
    Author: Schiaffella F, Fringuelli R, Cecchetti V, Fravolini A, Bruni G, Runci FM.
    Journal: Farmaco; 1989 Nov; 44(11):1031-44. PubMed ID: 2701961.
    Abstract:
    We report the synthesis of N-heterocyclic carboxamides of 5-methyl-4-oxo-2,3,4,5-tetrahydrothiopyrano [3,2-c][1,2]benzothiazine 6,6-dioxide, their antiinflammatory and analgesic activities and the attempts to obtain a corresponding sulfoxidate series. Compounds (II c) and (II l) showed a good antiinflammatory activity which is comparable to that of piroxicam. No compound showed any significant analgesic activity.
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