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  • Title: ent-Labdane Diterpenoids from the Aerial Parts of Eupatorium obtusissmum.
    Author: Castillo QA, Triana J, Eiroa JL, Calcul L, Rivera E, Wojtas L, Padrón JM, Boberieth L, Keramane M, Abel-Santos E, Báez LA, Germosén EA.
    Journal: J Nat Prod; 2016 Apr 22; 79(4):907-13. PubMed ID: 27023255.
    Abstract:
    Six new ent-labdane diterpenoids, uasdlabdanes A-F (1-6), were isolated from the aerial parts of Eupatorium obtusissmum. The new structures were elucidated through spectroscopic and spectrometric data analyses. The absolute configurations of compounds 1 and 2 were established by X-ray crystallography, and those of 3-6, by comparison of experimental and calculated electronic circular dichroism spectra. The antiproliferative activity of the compounds was studied in a panel of six representative human solid tumor cell lines and showed GI50 values ranging from 19 to >100 μM.
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