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  • Title: [The role of cellular immunity in the pathogenesis of glomerulonephritis].
    Author: Kacprzyk F, Orłowski Z.
    Journal: Postepy Hig Med Dosw; 1989; 43(2-4):199-212. PubMed ID: 2702352.
    Abstract:
    In this article, experimental data and clinical observations suggesting the role of cell-mediated immunity in pathogenesis of primary glomerulonephritis have been presented. Serum anti-GBM antibodies have been observed in glomerulopathies mediated by anti-glomerular basement membrane antibodies with the presence of immunoglobulins in glomeruli and in their eluates. The lymphocytes from patients with glomerular disease show cell-mediated immune reactivity against GBM antigens. Cell-mediated immune mechanisms with involvement of mononuclear cells and polymorphonuclear leukocytes may participate in the pathogenesis of various forms of glomerulonephritis and contribute to prompt deterioration of renal function.
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