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Title: Localization of human c-mos to chromosome band 8q11 in leukemic cells with the t(8;21) (q22;q22). Author: Morris CM, Bowen J, Fitzgerald PH. Journal: Hum Genet; 1989 Mar; 81(4):339-42. PubMed ID: 2703237. Abstract: Chromosome in situ hybridization studies locate c-mos to chromosome band 8q11 in leukemic cells carrying the t(8;21) (q22;q22). This amends the previous assignment of c-mos to chromosome band 8q22 and conforms with its recent assignment to 8q11 in normal cells and in a cell line with a structurally abnormal chromosome 8. C-mos lies proximally to, and distant from, the breakpoint at 8q22 in the t(8;21) and is unlikely to have a role in the onset of acute myeloid leukemia characterized by this translocation.[Abstract] [Full Text] [Related] [New Search]