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  • Title: Influence of the separation procedure on the properties of magnetic nanoparticles: Gaining in vitro stability and T1-T2 magnetic resonance imaging performance.
    Author: Guldris N, Argibay B, Kolen'ko YV, Carbó-Argibay E, Sobrino T, Campos F, Salonen LM, Bañobre-López M, Castillo J, Rivas J.
    Journal: J Colloid Interface Sci; 2016 Jun 15; 472():229-36. PubMed ID: 27038785.
    Abstract:
    Ultrasmall superparamagnetic iron oxide nanoparticles (USPIOs) coated with polyacrylic acid (PAA) were synthesized by a hydrothermal method in gram-scale quantity and extensively characterized. Only the nanoparticles subjected to an additional centrifugation step showed narrow size distribution, high polymeric coverage, and ideal superparamagnetism. In addition to improved physico-chemical properties, these nanoparticles feature high stability in vitro as well as dual T1-T2 performance as contrast agents (CAs) for magnetic resonance imaging (MRI), highlighting the importance of the additional separation step in obtaining material with the desired properties.
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