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  • Title: Afatinib-associated Stevens-Johnson syndrome in an EGFR-mutated lung cancer patient.
    Author: Doesch J, Debus D, Meyer C, Papadopoulos T, Schultz ES, Ficker JH, Brueckl WM.
    Journal: Lung Cancer; 2016 May; 95():35-8. PubMed ID: 27040849.
    Abstract:
    INTRODUCTION: Afatinib is a tyrosine kinase inhibitor (TKI), that has been approved for treating patients with epidermal growth factor receptor (EGFR) mutated advanced non-small-cell lung cancer (NSCLC). Stevens-Johnson syndrome (SJS) related to EGFR directed TKIs is a rare adverse event. CASE PRESENTATION: We report a case of a 79-year-old white female with EGFR-mutated, metastatic non-small-cell lung cancer treated with afatinib as first-line palliative treatment, who developed a SJS after two months of treatment. Discontinuation of the TKI and systemic glucocorticoid treatment led to improvement of symptoms and recovery. CONCLUSION: Severe adverse cutaneous drug reactions that predominantly involve the skin and mucous membranes during treatment with afatinib should alert clinicians to suspect SJS and react appropriately.
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