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  • Title: [Acute peptic lesions of the gastroduodenal mucosa in patients with obstructive jaundice].
    Author: Upyrev AV, Gusev EIu, Il'ichev VA, Gorchakov VK, Muratova OA.
    Journal: Khirurgiia (Mosk); 1989 Jan; (1):42-6. PubMed ID: 2704159.
    Abstract:
    Complex study of the gastric acid-producing activity, the condition of the gastroduodenal mucosa, and the serum gastrin concentration in 80 patients with obstructive jaundice showed that the appearance of acute erosive-ulcerative injuries of the mucosa of the gastroduodenal zone depended on the increase of activity of the peptic factor of the gastric medium. Peptic complications occurred in 27.1% of patients with initial normo and hyperacidity and a high level of blood gastrin. The absence of bile in the duodenum (obstructive jaundice, by-pass biliodigestive anastomoses) stimulated the peptic factor. This is evidently linked with secretin deficiency (absence of the effect of bile on the secretin producing S-cells) leading to weakened inhibiting effect of secretin on the serum gastrin content, which results in hypergastrinemia and hyperacidity.
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