These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Associations between the FAS -670 A/G, -1377 G/A, and FASL -844 T/C polymorphisms and susceptibility to systemic lupus erythematosus: a meta-analysis.
    Author: Lee YH, Song GG.
    Journal: Clin Exp Rheumatol; 2016; 34(4):634-40. PubMed ID: 27050822.
    Abstract:
    OBJECTIVES: The aim of this study was to determine whether the FAS, and FASL polymorphisms are associated with susceptibility to systemic lupus erythematosus (SLE). METHODS: A meta-analysis was conducted on the associations between the FAS -670 A/G, FAS -1377 G/A, and FASL -844 T/C polymorphisms and SLE. RESULTS: A total of eleven articles met the study inclusion criteria. Meta-analysis indicated an association between SLE and the FAS -670 A/G polymorphism in the dominant model (OR=0.629, 95% CI=0.409-0.967, p=0.035). Stratification by ethnicity indicated an association between the FAS -670 GG+GA genotype and SLE in Asian populations (OR=0.464, 95% CI=0.218-0.988, p=0.046). Meta-analysis indicated an association between SLE and the FAS -1377 AA+AG genotype (OR=0.712, 95% CI=0.528 - 0.961, p=0.027), and an association between SLE and the FASL +844 C allele was found (OR=1.377, 95% CI=1.162 - 1.633, p=2.3x10(-4)). Meta-analyses using the recessive model or homozygote contrast showed the same pattern as the meta-analysis of the FASL +844 C allele, that is, a significant association with SLE. CONCLUSIONS: This meta-analysis demonstrates that the FAS -670 A/G, FAS -1377 G/A, and FASL -844 T/C polymorphisms are associated with susceptibility to SLE.
    [Abstract] [Full Text] [Related] [New Search]