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  • Title: Stability of liver proton density fat fraction and changes in R 2* measurements induced by administering gadoxetic acid at 3T MRI.
    Author: Sofue K, Zhong X, Nickel MD, Dale BM, Bashir MR.
    Journal: Abdom Radiol (NY); 2016 Aug; 41(8):1555-64. PubMed ID: 27052456.
    Abstract:
    OBJECTIVE: To assess changes in liver proton density fat fraction (PDFF) and R 2* measurements in the presence of changes in tissue relaxation rates induced by administrating gadoxetic acid, using two different image reconstruction methods at 3T MRI. METHODS: Forty-five patients were imaged at 3T with chemical-shift-based MRI sequences before and 20 min after administration of gadoxetic acid. Image reconstructions were performed using hybrid and complex methods to obtain PDFF and R 2* images. A single radiologist measured PDFF and R 2* values on precontrast and postcontrast images. Precontrast and postcontrast PDFF values were compared using intraclass correlation coefficient (ICC), linear regression, and Bland-Altman analysis. Changes in R 2* values from precontrast to postcontrast were correlated with relative liver enhancement (RLE) based on signal intensities on T 1-weighted images using Spearman's rank correlation. RESULTS: PDFF values were similar between precontrast and postcontrast images (ICC = 0.99, linear regression slopes = 0.98, mean difference = -0.21 to -0.31%). PDFF measurements were stable between precontrast and postcontrast images. Changes in R 2* values were correlated with RLE (p < 0.001, r = 0.49-0.71). CONCLUSIONS: PDFF measurements from both image reconstruction methods are stable in the presence of changes in tissue relaxation rates after administering gadoxetic acid at 3T MRI. Changes in R 2* values correlate with established measures of gadoxetic acid uptake based on T 1-weighted images.
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