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  • Title: The effect on the cornea of alpha cyclodextrin vehicle for cyclosporin eye drops.
    Author: Kanai A, Alba RM, Takano T, Kobayashi C, Nakajima A, Kurihara K, Yokoyama T, Fukami M.
    Journal: Transplant Proc; 1989 Feb; 21(1 Pt 3):3150-2. PubMed ID: 2705275.
    Abstract:
    We tested four different combinations of alpha-CD and CYA: 0.075% and 80 mg/mL alpha-CD, 0.025% CYA and 40 mg/mL alpha-CD, 0.009% CYA and 20 mg/mL alpha-CD, and 0.003% CYA and 10 mg/mL alpha-CD. We found that 0.025% CYA (alpha-CD[40 mg/mL]) resulted in the least corneal toxicity and penetrated in the cornea 5 to 10 times more than did lipophilic vehicle with CYA.
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