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  • Title: Inhibition of rat heart and liver microsomal lipid peroxidation by nifedipine.
    Author: Engineer F, Sridhar R.
    Journal: Biochem Pharmacol; 1989 Apr 15; 38(8):1279-85. PubMed ID: 2706019.
    Abstract:
    Lipid peroxidation in rat heart and liver microsomes was induced by an NADPH-generating system or by ascorbate in the presence of an ADP-iron complex. Microsomal lipid peroxidation, as measured by malonaldehyde formation, was inhibited by nifedipine over a wide range of concentrations (47 microM to 6 mM). Nifedipine also decreased the oxygen consumption of cardiac and hepatic microsomes in a concentration-dependent manner. These results indicate that nifedipine may perturb microsomal electron transport systems. Nifedipine may have the potential to alter the sensitivity of cardiac and hepatic membranes to peroxidative damage.
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