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  • Title: Determination of albendazole sulfoxide in human plasma by using liquid chromatography-tandem mass spectrometry.
    Author: Saraner N, Özkan GY, Güney B, Alkan E, Burul-Bozkurt N, Sağlam O, Fikirdeşici E, Yıldırım M.
    Journal: J Chromatogr B Analyt Technol Biomed Life Sci; 2016 Jun 01; 1022():1-5. PubMed ID: 27060508.
    Abstract:
    A rapid, simple and sensitive method was developed and validated using liquid chromatography-tandem mass spectrometry (LC-MS/MS) for determination of albendazole sulfoxide (ABZOX) in human plasma. The plasma samples were extracted by protein precipitation using albendazole sulfoxide-d3 as internal standard (IS). The chromatographic separation was performed on Waters Xbridge C18Column (100×4.6mm, 3.5μm) with a mobile phase consisting of ammonia solution, water and methanol at a flow rate of 0.70mL/min. ABZOX was detected and identified by mass spectrometry with electrospray ionization (ESI) in positive ion and multiple-reaction monitoring (MRM) mode. The method was linear in the range of 3-1500ng/mL for ABZOX. This method was successfully applied to the bioequivalence study in human plasma samples.
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