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  • Title: Progression and Natural History of Nonalcoholic Fatty Liver Disease in Adults.
    Author: Marengo A, Jouness RI, Bugianesi E.
    Journal: Clin Liver Dis; 2016 May; 20(2):313-24. PubMed ID: 27063271.
    Abstract:
    Liver-related mortality is the third cause of death in patients with nonalcoholic fatty liver disease, but the long-term prognosis basically depends on the presence and severity of liver damage. Thus, life expectancy in patients with simple steatosis is not different from the general population, but liver-related mortality is significantly higher in patients with nonalcoholic steatohepatitis (NASH), particularly in those with advanced fibrosis. Progression of liver disease is observed in up to one-third of patients with NASH. The long-term hepatic prognosis mostly depends on the histologic stage at initial liver biopsy, but multiple risk factors may concur.
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