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  • Title: Sensitivity of ERG components from dark-adapted goldfish retinas treated with APB.
    Author: DeMarco PJ, Powers MK.
    Journal: Brain Res; 1989 Mar 20; 482(2):317-23. PubMed ID: 2706490.
    Abstract:
    The electroretinogram (ERG) of the dark-adapted goldfish was examined before and after intravitreal injection of DL-2-amino-4-phosphonobutyric acid (APB). APB abolished the b-wave and decreased absolute sensitivity of the remaining waveform, which was composed of a vitreal-negative component followed by a vitreal-positive component. The sensitivity, time course and amplitude of these components differed from ERGs obtained from animals treated with sodium aspartate. Spectral sensitivity of both post-APB components closely resembled that of the normal dark-adapted b-wave. The results suggest that APB does not act selectively on any particular class of photoreceptors or photoreceptor pathways in the dark-adapted goldfish retina.
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