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  • Title: [Effect of 11-deoxyprostaglandins E on the reproductive system].
    Author: Murinova MIu, Bagaeva SG, Adler ME, Davydova VA, Lazareva DN.
    Journal: Farmakol Toksikol; 1989; 52(1):50-3. PubMed ID: 2707422.
    Abstract:
    The pharmacological properties of 4 derivatives of 11-desoxy-prostaglandins E (uterotonic, luteolytic, hypotensive, anti-inflammatory, diarrhogenic ones and also acute toxicity) were studied. Compound I possessed the uterotonic activity which decreased with an alpha-chain elongation and a radical introduction into a benzene ring. Compounds I and II exhibited the luteotropic properties at low doses and the luteolytic ones at high doses. The compounds under study had the hypotensive activity due to the presence of a benzene ring in a W-chain.
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