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  • Title: Genetic code preferentially conserves long-range interactions among the amino acids.
    Author: Sitaramam V.
    Journal: FEBS Lett; 1989 Apr 10; 247(1):46-50. PubMed ID: 2707450.
    Abstract:
    The physical properties of amino acids were investigated in order to evaluate their possible relationship to the assignment of codons for amino acids in the genetic code. A comparison of the interconversion probability between amino acids and the distances between the amino acids for individual physical properties revealed a striking hierarchy among the physical properties. Surprisingly, it is the long-range/solvent interactions and not the short-range/stereochemical properties which are preferentially conserved in the genetic code.
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