These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effect of poly-glutamate on uptake efficiency and cytotoxicity of cell penetrating peptides.
    Author: Farkhani SM, Shirani A, Mohammadi S, Zakeri-Milani P, Shahbazi Mojarrad J, Valizadeh H.
    Journal: IET Nanobiotechnol; 2016 Apr; 10(2):87-95. PubMed ID: 27074859.
    Abstract:
    Cell penetrating peptides (CPPs) were developed as vehicles for efficient delivery of various molecules. An ideal CPP-peptide should not display any toxicity against cancer cells as well as healthy cells and efficiently enter into the cell. Because of the cationic nature and the intrinsic vector capabilities, these peptides can cause cytotoxicity. One of the possible reasons for toxicity of CPPs is direct translocation and consequently, pore formation on the plasma membrane. In this study it was demonstrated that interaction of poly-glutamate with CPP considerably reduced their cytotoxicity in A549 cell. This strategy could be useful for efficient drug delivery mediated by CPP.
    [Abstract] [Full Text] [Related] [New Search]