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  • Title: Low molecular weight immunosuppressors secreted by adult Nematospiroides dubius.
    Author: Monroy FG, Dobson C, Adams JH.
    Journal: Int J Parasitol; 1989 Feb; 19(1):125-7. PubMed ID: 2707958.
    Abstract:
    Adult Nematospiroides dubius excretory-secretory products (ES) were collected from worms cultured in vitro, separated by sodium dodecyl sulphate--polyacrylamide gel electrophoresis (SDS-PAGE) into four fractions (FI-IV), electroeluted and assessed for their ability to inhibit the proliferation of mouse lymphocytes stimulated by mitogens in vitro. The proliferation of mitogen- and ES-stimulated mouse spleen lymphocytes from normal and infected mice was inhibited by low mol. wt ES F-IV (less than 26,000).
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