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  • Title: Copper-catalyzed alkylarylation of activated alkenes using isocyanides as the alkyl source: an efficient radical access to 3,3-dialkylated oxindoles.
    Author: Zhao Y, Li Z, Sharma UK, Sharma N, Song G, Van der Eycken EV.
    Journal: Chem Commun (Camb); 2016 May 11; 52(38):6395-8. PubMed ID: 27086905.
    Abstract:
    A novel and efficient protocol for the synthesis of 3,3-dialkylated oxindoles is described. The method involves a copper-catalyzed tandem radical addition/cyclization of N-arylacrylamides with the alkyl radicals generated from isocyanides. Two C-C bonds are formed in a single step.
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