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  • Title: Analgesic, anti-inflammatory and anti-pyretic activities of Thymus linearis.
    Author: Qadir MI, Parveen A, Abbas K, Ali M.
    Journal: Pak J Pharm Sci; 2016 Mar; 29(2):591-4. PubMed ID: 27087102.
    Abstract:
    The present study was aimed to investigate the antipyretic, analgesic and anti-inflammatory activity of aqueous methanolic and n-hexane extract of Thymus linearis. For measuring analgesic activity, writhing test, hot plate method and formalin test were performed and abdominal writhing was induced by intra-peritoneal injection of 0.2 ml of 3% acetic acid. While in formalin test, pain was experimentally induced by injecting 25 μl of 2.5% formalin in left hind paw. In hot plate method, pain was induced thermally by keeping the animals on a hot plate with temperature of about 51°C. Anti-inflammatory activity was assessed by carrageenan induced mice paw edema. For determination of antipyretic activity, pyrexia was induced by subcutaneous injection of 15% yeast. The results showed that both the extracts had significant analgesic activity (p<0.05); anti-inflammatory activity (p<0.05) and anti-pyretic activity (p<0.05). Therefore, it was concluded from this study that the extracts of Thymus linearis may be used against pain, pyrexia and inflammation.
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