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  • Title: Tissue distribution of cocaine in a pregnant woman.
    Author: Mittleman RE, Cofino JC, Hearn WL.
    Journal: J Forensic Sci; 1989 Mar; 34(2):481-6. PubMed ID: 2708961.
    Abstract:
    Reports of cocaine-related obstetrical problems, including abruptio placentae and spontaneous abortion, have become increasingly evident in the medical literature; however, little is known about tissue distribution of cocaine in the pregnant woman. We report the toxicologic results of distribution studies performed on a pregnant woman and her fetus. Maternal/fetal cocaine concentration ratios were high when comparing blood (9:1), brain (6:5), and kidney (10:6). Possible explanations of the mechanism for lower fetal cocaine concentrations may include uterine vasoconstriction, incomplete maternal/fetal equalibration, or rapid placental/fetal clearance.
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